Hesperian Health Guides

Medicine Combinations to Treat Gonorrhea and Chlamydia

Sexually Transmitted Infections: Medicines

Gonorrhea and chlamydia often occur together, so they are both treated at the same time even if you don't know which one it is. To do this, use 2 medicines, one from each section below. For each section, the best choices are listed first and in order of next best after that. For example, the best combination is ceftriaxone and azithromycin.

Also treat the person’s sexual partner or partners with the same medicines.






Medicine How much to give How to use
ceftriaxone
250 mg
(In some countries, 500 mg may be recommended instead)
inject into muscle, 1 time only
or cefixime 400 mg by mouth, 1 time only
or
spectinomycin
2 grams (2000 mg) inject into muscle, 1 time only
AND
azithromycin 1 gram (1000 mg) by mouth, 1 time only
or doxycycline
(do not use doxycycline if you are pregnant and avoid using it if you are breastfeeding)
100 mg by mouth, 2 times a day for 7 days
or erythromycin 500 mg by mouth, 4 times a day for 7 days


This page was updated:05 Jan 2024