Hesperian Health Guides
Medicine Combinations to Treat Both Syphilis and Chancroid
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It is not always possible to tell the difference between chancroid and syphilis. If you are not sure whether the person has one or the other or both, it is best to treat both at the same time. Choose 1 medicine from each box. For each section, the best choices are listed first and in order of next best after that. For example, the best combination is benzathine penicillin and azithromycin. If using erythromycin to treat syphilis, don’t use azithromycin or erythromycin for chancroid.
|Medicine to treat syphilis. Use one.||How much to give||How to use|
|benzathine penicillin (can be used if pregnant)||2.4 million Units||inject into muscle, one time only|
(do not use doxycycline if you are pregnant and avoid use if you are breastfeeding)
|100 mg||by mouth, 2 times a day for 14 days|
(Only use this if you are pregnant or breastfeeding and allergic to penicillin. It will treat syphilis in the mother, but after the birth the baby will need additional treatment)
|500 mg||by mouth, 4 times a day for 15 days|
|Medicine to treat chancroid. Use one.||How much to give||How to use|
|azithromycin||1 gram (1000 mg)||by mouth, one time only|
|or ceftriaxone||250 mg||inject into muscle, one time only|
(do not use if pregnant or breastfeeding or under age 16)
|500 mg||by mouth, 2 times a day for 3 days|
|or erythromycin||500 mg||by mouth, 4 times a day for 7 days|